5K69
Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T224
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | GLU213 |
| A | HIS214 |
| A | PHE215 |
| A | ILE291 |
| A | TRP394 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | PHE200 |
| A | TRP210 |
| A | HOH608 |
| A | ILE188 |
| A | LYS189 |
| A | ILE190 |
| A | GLY198 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue 6QR A 503 |
| Chain | Residue |
| A | MET303 |
| A | TYR318 |
| A | THR320 |
| A | GLY332 |
| A | HIS336 |
| A | TRP340 |
| A | SER351 |
| A | HIS352 |
| A | GLY353 |
| A | CYS354 |
| A | ASN356 |
| A | HOH665 |
| A | HOH694 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| B | GLU213 |
| B | HIS214 |
| B | PHE215 |
| B | ILE291 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide 6QR B 502 and CYS B 354 |
| Chain | Residue |
| B | SER279 |
| B | MET280 |
| B | MET303 |
| B | TYR318 |
| B | GLY332 |
| B | PHE334 |
| B | HIS336 |
| B | TRP340 |
| B | SER351 |
| B | HIS352 |
| B | GLY353 |
| B | LEU355 |
| B | ASN356 |
| B | HOH605 |
| B | HOH727 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 250 |
| Details | Domain: {"description":"L,D-TPase catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU01373","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01373","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23519417","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU01373","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23519417","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Binds to carbapenem drug (covalent)"} |
| Chain | Residue | Details |
