5K32
PDE4D crystal structure in complex with small molecule inhibitor
Summary for 5K32
Entry DOI | 10.2210/pdb5k32/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | phosphodiesterases, inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Apical cell membrane : Q08499 |
Total number of polymer chains | 2 |
Total formula weight | 77695.30 |
Authors | Segarra, V.,Hernandez, B.,Roberts, R.,Gracia, J.,Soler, M.,Bonin, I.,Aymami, J. (deposition date: 2016-05-19, release date: 2017-03-29, Last modification date: 2024-01-10) |
Primary citation | Roberts, R.S.,Sevilla, S.,Ferrer, M.,Taltavull, J.,Hernandez, B.,Segarra, V.,Gracia, J.,Lehner, M.D.,Gavalda, A.,Andres, M.,Cabedo, J.,Vilella, D.,Eichhorn, P.,Calama, E.,Carcasona, C.,Miralpeix, M. 4-Amino-7,8-dihydro-1,6-naphthyridin-5(6 H)-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure-Activity Relationships. J. Med. Chem., 61:2472-2489, 2018 Cited by PubMed: 29502405DOI: 10.1021/acs.jmedchem.7b01751 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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