1.9 angstrom A2a adenosine receptor structure with sulfur SAD phasing and phase extension using XFEL data

Summary for 5K2C

Related5K2A 5K2B 5K2D
DescriptorAdenosine receptor A2a/Soluble cytochrome b562 chimera, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, SODIUM ION, ... (8 entities in total)
Functional Keywordsa2a adenosine receptor, sulfur sad, gpcr, membrane protein, structural genomics, psi-biology, gpcr network
Biological sourceHomo sapiens, Escherichia coli (Human)
Total number of polymer chains1
Total molecular weight58273.16
Primary citation
Batyuk, A.,Galli, L.,Ishchenko, A.,Han, G.W.,Gati, C.,Popov, P.A.,Lee, M.Y.,Stauch, B.,White, T.A.,Barty, A.,Aquila, A.,Hunter, M.S.,Liang, M.,Boutet, S.,Pu, M.,Liu, Z.J.,Nelson, G.,James, D.,Li, C.,Zhao, Y.,Spence, J.C.,Liu, W.,Fromme, P.,Katritch, V.,Weierstall, U.,Stevens, R.C.,Cherezov, V.
Native phasing of x-ray free-electron laser data for a G protein-coupled receptor.
Sci Adv, 2:e1600292-e1600292, 2016
PubMed: 27679816 (PDB entries with the same primary citation)
DOI: 10.1126/sciadv.1600292
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20840 1.3% 17.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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