5K27
Crystal structure of ancestral protein ancMT of ADP-dependent sugar kinases family.
Summary for 5K27
Entry DOI | 10.2210/pdb5k27/pdb |
Descriptor | ancMT, ADENOSINE MONOPHOSPHATE, IODIDE ION, ... (4 entities in total) |
Functional Keywords | ancestral protein reconstruction, adp-dependent sugar kinases family, glucokinase, phosphofructokinase, bifuncional enzymes, enzyme evolution, transferase |
Biological source | synthetic construct |
Total number of polymer chains | 2 |
Total formula weight | 109955.36 |
Authors | Castro-Fernandez, V.,Herrera-Morande, A.,Zamora, R.,Merino, F.,Pereira, H.M.,Brandao-Neto, J.,Garratt, R.,Guixe, V. (deposition date: 2016-05-18, release date: 2017-05-24, Last modification date: 2023-09-27) |
Primary citation | Castro-Fernandez, V.,Herrera-Morande, A.,Zamora, R.,Merino, F.,Gonzalez-Ordenes, F.,Padilla-Salinas, F.,Pereira, H.M.,Brandao-Neto, J.,Garratt, R.C.,Guixe, V. Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases. J. Biol. Chem., 292:21218-21218, 2017 Cited by PubMed: 29273585DOI: 10.1074/jbc.AAC117.001147 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.58 Å) |
Structure validation
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