5K1V

Crystal structure of Endoplasmic Reticulum aminopeptidase 2 (ERAP2) in complex with a diaminobenzoic acid derivative ligand.

5K1V の概要

• エントリーDOI: 10.2210/pdb5k1v/pdb
• 分子名称: Endoplasmic reticulum aminopeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: endoplasmic reticulum aminopeptidase, hydrolase, zinc-binding metallopeptidase, diaminobenzoic acid derivative
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 228025.33

構造登録者

Saridakis, E.,Papakyriakou, A.,Giastas, P.,Mpakali, A.,Mavridis, I.M.,Stratikos, E. (登録日: 2016-05-18, 公開日: 2017-03-29, 最終更新日: 2024-01-10)

• 主引用文献: Mpakali, A.,Giastas, P.,Deprez-Poulain, R.,Papakyriakou, A.,Koumantou, D.,Gealageas, R.,Tsoukalidou, S.,Vourloumis, D.,Mavridis, I.M.,Stratikos, E.,Saridakis, E.; Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.; ACS Med Chem Lett, 8:333-337, 2017; PubMed: 28337326; DOI: 10.1021/acsmedchemlett.6b00505

実験手法

X-RAY DIFFRACTION (2.897 Å)