5K0H

Human factor Xa in complex with synthetic inhibitor benzylsulfonyl-dSer(Benzyl)-Gly-4-amidinobenzylamide

Summary for 5K0H

• Entry DOI: 10.2210/pdb5k0h/pdb
• Descriptor: Coagulation factor X, CALCIUM ION, O-benzyl-N-(benzylsulfonyl)-D-seryl-N-[(4-carbamimidoylphenyl)methyl]glycinamide, ... (5 entities in total)
• Functional Keywords: human factor xa, inhibitor complex, benzamidine inhibitor, hydrolase, clotting factor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32524.95

Authors

Steinmetzer, T. (deposition date: 2016-05-17, release date: 2016-07-06, Last modification date: 2024-01-10)

• Primary citation: Schweinitz, A.,Sturzebecher, A.,Sturzebecher, U.,Schuster, O.,Sturzebecher, J.,Steinmetzer, T.; New substrate analogue inhibitors of factor Xa containing 4-amidinobenzylamide as P1 residue: part 1.; Medicinal Chemistry, 2:349-361, 2006; PubMed: 16848746; DOI: 10.2174/157340606777724040

Experimental method

X-RAY DIFFRACTION (2.2 Å)