5JY3
CRYSTAL STRUCTURE OF LXRbeta (NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 2) COMPLEXED WITH BMS-852927
Summary for 5JY3
Entry DOI | 10.2210/pdb5jy3/pdb |
Descriptor | Oxysterols receptor LXR-beta, 2-[2-[2-[2,6-bis(chloranyl)phenyl]propan-2-yl]-1-[2-fluoranyl-4-[3-fluoranyl-4-(hydroxymethyl)-5-methylsulfonyl-phenyl] phenyl]imidazol-4-yl]propan-2-ol, 1,4-BUTANEDIOL, ... (4 entities in total) |
Functional Keywords | nhr, nr1h2, lxr-b, lxrb, unr, ner-i, rip15, ner, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P55055 |
Total number of polymer chains | 4 |
Total formula weight | 124789.70 |
Authors | Muckelbauer, J.K. (deposition date: 2016-05-13, release date: 2016-11-02, Last modification date: 2024-03-06) |
Primary citation | Kick, E.K.,Busch, B.B.,Martin, R.,Stevens, W.C.,Bollu, V.,Xie, Y.,Boren, B.C.,Nyman, M.C.,Nanao, M.H.,Nguyen, L.,Plonowski, A.,Schulman, I.G.,Yan, G.,Zhang, H.,Hou, X.,Valente, M.N.,Narayanan, R.,Behnia, K.,Rodrigues, A.D.,Brock, B.,Smalley, J.,Cantor, G.H.,Lupisella, J.,Sleph, P.,Grimm, D.,Ostrowski, J.,Wexler, R.R.,Kirchgessner, T.,Mohan, R. Discovery of Highly Potent Liver X Receptor beta Agonists. ACS Med Chem Lett, 7:1207-1212, 2016 Cited by PubMed: 27994765DOI: 10.1021/acsmedchemlett.6b00234 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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