5JY3

CRYSTAL STRUCTURE OF LXRbeta (NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 2) COMPLEXED WITH BMS-852927

5JY3 の概要

• エントリーDOI: 10.2210/pdb5jy3/pdb
• 分子名称: Oxysterols receptor LXR-beta, 2-[2-[2-[2,6-bis(chloranyl)phenyl]propan-2-yl]-1-[2-fluoranyl-4-[3-fluoranyl-4-(hydroxymethyl)-5-methylsulfonyl-phenyl] phenyl]imidazol-4-yl]propan-2-ol, 1,4-BUTANEDIOL, ... (4 entities in total)
• 機能のキーワード: nhr, nr1h2, lxr-b, lxrb, unr, ner-i, rip15, ner, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P55055
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 124789.70

構造登録者

Muckelbauer, J.K. (登録日: 2016-05-13, 公開日: 2016-11-02, 最終更新日: 2024-03-06)

• 主引用文献: Kick, E.K.,Busch, B.B.,Martin, R.,Stevens, W.C.,Bollu, V.,Xie, Y.,Boren, B.C.,Nyman, M.C.,Nanao, M.H.,Nguyen, L.,Plonowski, A.,Schulman, I.G.,Yan, G.,Zhang, H.,Hou, X.,Valente, M.N.,Narayanan, R.,Behnia, K.,Rodrigues, A.D.,Brock, B.,Smalley, J.,Cantor, G.H.,Lupisella, J.,Sleph, P.,Grimm, D.,Ostrowski, J.,Wexler, R.R.,Kirchgessner, T.,Mohan, R.; Discovery of Highly Potent Liver X Receptor beta Agonists.; ACS Med Chem Lett, 7:1207-1212, 2016; PubMed: 27994765; DOI: 10.1021/acsmedchemlett.6b00234

実験手法

X-RAY DIFFRACTION (2.4 Å)