5JXH

Structure the proprotein convertase furin in complex with meta-guanidinomethyl-Phac-RVR-Amba at 2.0 Angstrom resolution.

5JXH の概要

• エントリーDOI: 10.2210/pdb5jxh/pdb
• 関連するBIRD辞書のPRD_ID: PRD_001220
• 分子名称: Furin, 2UC-ARG-VAL-ARG-00S, CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: protease, inhibitor, proteolysis, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P09958
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53372.17

構造登録者

Dahms, S.O.,Arciniega, M.,Steinmetzer, T.,Huber, R.,Than, M.E. (登録日: 2016-05-13, 公開日: 2016-10-05, 最終更新日: 2024-01-10)

• 主引用文献: Dahms, S.O.,Arciniega, M.,Steinmetzer, T.,Huber, R.,Than, M.E.; Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.; Proc.Natl.Acad.Sci.USA, 113:11196-11201, 2016; PubMed: 27647913; DOI: 10.1073/pnas.1613630113

実験手法

X-RAY DIFFRACTION (2 Å)