5JWM
Bivalent BET Bromodomain Inhibition
Summary for 5JWM
Entry DOI | 10.2210/pdb5jwm/pdb |
Descriptor | Bromodomain-containing protein 4, 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]ethanamide (3 entities in total) |
Functional Keywords | bivalent-ligand, bromodomain, inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 2 |
Total formula weight | 31254.86 |
Authors | Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2016-05-12, release date: 2016-07-06, Last modification date: 2023-09-27) |
Primary citation | Tanaka, M.,Roberts, J.M.,Seo, H.S.,Souza, A.,Paulk, J.,Scott, T.G.,DeAngelo, S.L.,Dhe-Paganon, S.,Bradner, J.E. Design and characterization of bivalent BET inhibitors. Nat.Chem.Biol., 12:1089-1096, 2016 Cited by PubMed: 27775715DOI: 10.1038/nchembio.2209 PDB entries with the same primary citation |
Experimental method |
Structure validation
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