5JWM

Bivalent BET Bromodomain Inhibition

5JWM の概要

• エントリーDOI: 10.2210/pdb5jwm/pdb
• 分子名称: Bromodomain-containing protein 4, 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]ethanamide (3 entities in total)
• 機能のキーワード: bivalent-ligand, bromodomain, inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31254.86

構造登録者

Seo, H.-S.,Dhe-Paganon, S. (登録日: 2016-05-12, 公開日: 2016-07-06, 最終更新日: 2023-09-27)

• 主引用文献: Tanaka, M.,Roberts, J.M.,Seo, H.S.,Souza, A.,Paulk, J.,Scott, T.G.,DeAngelo, S.L.,Dhe-Paganon, S.,Bradner, J.E.; Design and characterization of bivalent BET inhibitors.; Nat.Chem.Biol., 12:1089-1096, 2016; PubMed: 27775715; DOI: 10.1038/nchembio.2209

実験手法

X-RAY DIFFRACTION (1.71 Å)