5JTC

Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese, 2,4-pyridine dicarboxylate and factor X substrate peptide fragment(39mer-4Ser)

5JTC の概要

• エントリーDOI: 10.2210/pdb5jtc/pdb
• 分子名称: Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, MANGANESE (II) ION, ... (7 entities in total)
• 機能のキーワード: 2-oxoglutarate dependent oxygenase, aspartyl/asparaginyl beta-hydroxylase, egf-like domain hydroxylase, double stranded beta-helix, tetratricopeptide repeat, oxidoreductase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Isoform 1: Endoplasmic reticulum membrane; Single-pass type II membrane protein . Isoform 4: Sarcoplasmic reticulum membrane; Single-pass type II membrane protein . Isoform 8: Endoplasmic reticulum membrane; Single-pass type II membrane protein : Q12797; Secreted: P00742
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53989.78

構造登録者

McDonough, M.A.,Pfeffer, I. (登録日: 2016-05-09, 公開日: 2017-05-24, 最終更新日: 2024-01-10)

• 主引用文献: Brewitz, L.,Tumber, A.,Pfeffer, I.,McDonough, M.A.,Schofield, C.J.; Aspartate/asparagine-beta-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.; Sci Rep, 10:8650-8650, 2020; PubMed: 32457455; DOI: 10.1038/s41598-020-65123-9

実験手法

X-RAY DIFFRACTION (2.24 Å)