5JSB

Crystal structure of Mcl1-inhibitor complex

Summary for 5JSB

• Entry DOI: 10.2210/pdb5jsb/pdb
• Related: 4OYD 5JSN
• Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 inhibitor (3 entities in total)
• Functional Keywords: mcl-1, antimcl1, complex, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 202323.85

Authors

Shen, B.W.,Stoddard, B.L. (deposition date: 2016-05-07, release date: 2016-11-16, Last modification date: 2024-04-03)

• Primary citation: Berger, S.,Procko, E.,Margineantu, D.,Lee, E.F.,Shen, B.W.,Zelter, A.,Silva, D.A.,Chawla, K.,Herold, M.J.,Garnier, J.M.,Johnson, R.,MacCoss, M.J.,Lessene, G.,Davis, T.N.,Stayton, P.S.,Stoddard, B.L.,Fairlie, W.D.,Hockenbery, D.M.,Baker, D.; Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.; Elife, 5:-, 2016; PubMed: 27805565; DOI: 10.7554/eLife.20352

Experimental method

X-RAY DIFFRACTION (2.74 Å)