5JR7
Crystal structure of an ACRDYS heterodimer [RIa(92-365):C] of PKA
Summary for 5JR7
Entry DOI | 10.2210/pdb5jr7/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type I-alpha regulatory subunit, ADENOSINE-5'-DIPHOSPHATE (3 entities in total) |
Functional Keywords | pka signaling, ria subunit, disease mutations, dysfunctional acrdys mutant, transferase-camp binding protein complex, transferase/camp binding protein |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 4 |
Total formula weight | 144155.18 |
Authors | Bruystens, J.G.H.,Wu, J.,Taylor, S.S. (deposition date: 2016-05-05, release date: 2017-03-15, Last modification date: 2023-09-27) |
Primary citation | Bruystens, J.G.,Wu, J.,Fortezzo, A.,Del Rio, J.,Nielsen, C.,Blumenthal, D.K.,Rock, R.,Stefan, E.,Taylor, S.S. Structure of a PKA RI alpha Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J. Mol. Biol., 428:4890-4904, 2016 Cited by PubMed: 27825928DOI: 10.1016/j.jmb.2016.10.033 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.56 Å) |
Structure validation
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