5JQ6

Crystal structure of ClfA in complex with the Fab fragment of Tefibazumab

Summary for 5JQ6

Entry DOI	10.2210/pdb5jq6/pdb
Descriptor	Clumping factor A, Tefibazumab FAB FRAGMENT HEAVY CHAIN, Tefibazumab FAB FRAGMENT LIGHT CHAIN, ... (4 entities in total)
Functional Keywords	staphylococcal infections, clumping factor a, fibrinogen, tefibazumab, aurexis, mscramm, immune system
Biological source	Staphylococcus aureus More
Total number of polymer chains	3
Total formula weight	83295.59
Authors	Ganesh, V.K. (deposition date: 2016-05-04, release date: 2017-01-18, Last modification date: 2023-09-27)
Primary citation	Ganesh, V.K.,Liang, X.,Geoghegan, J.A.,Cohen, A.L.,Venugopalan, N.,Foster, T.J.,Hook, M. Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody. EBioMedicine, 13:328-338, 2016 Cited by PubMed: 27789272 DOI: 10.1016/j.ebiom.2016.09.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation