5JQ3

Crystal structure of Ebola glycoprotein

Summary for 5JQ3

• Entry DOI: 10.2210/pdb5jq3/pdb
• Descriptor: Envelope glycoprotein 1,Envelope glycoprotein 1,Envelope glycoprotein 1, Envelope glycoprotein 2, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: ebola virus, filoviridae, envelope glycoprotein, protein inhibitor complex, ibuprofen, toremifene, viral protein
• Biological source: Ebola virus - Mayinga, Zaire, 1976; More
• Cellular location: GP2: Virion membrane ; Single-pass type I membrane protein . GP1: Virion membrane ; Peripheral membrane protein. GP2-delta: Secreted : Q05320
• Total number of polymer chains: 2
• Total formula weight: 57663.37

Authors

Zhao, Y.,Ren, J.,Stuart, D.I. (deposition date: 2016-05-04, release date: 2016-06-29, Last modification date: 2024-01-10)

• Primary citation: Zhao, Y.,Ren, J.,Harlos, K.,Jones, D.M.,Zeltina, A.,Bowden, T.A.,Padilla-Parra, S.,Fry, E.E.,Stuart, D.I.; Toremifene interacts with and destabilizes the Ebola virus glycoprotein.; Nature, 535:168-172, 2016; PubMed: 27362232; DOI: 10.1038/nature18615

Experimental method

X-RAY DIFFRACTION (2.23 Å)