5JQ1

Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactosamine mimic

5JQ1 の概要

• エントリーDOI: 10.2210/pdb5jq1/pdb
• 関連するPDBエントリー: 5JPV
• 分子名称: Asialoglycoprotein receptor 1, CALCIUM ION, N-[(1S,2R,3R,4R,5S)-2,3-dihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-4-yl]acetamide, ... (5 entities in total)
• 機能のキーワード: asialoglycoprotein receptor, carbohydrates, liver targeting, sugar binding protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform H1a: Membrane; Single-pass type II membrane protein. Isoform H1b: Secreted : P07306
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34765.50

構造登録者

Liu, S. (登録日: 2016-05-04, 公開日: 2017-06-14, 最終更新日: 2023-09-27)

• 主引用文献: Sanhueza, C.A.,Baksh, M.M.,Thuma, B.,Roy, M.D.,Dutta, S.,Preville, C.,Chrunyk, B.A.,Beaumont, K.,Dullea, R.,Ammirati, M.,Liu, S.,Gebhard, D.,Finley, J.E.,Salatto, C.T.,King-Ahmad, A.,Stock, I.,Atkinson, K.,Reidich, B.,Lin, W.,Kumar, R.,Tu, M.,Menhaji-Klotz, E.,Price, D.A.,Liras, S.,Finn, M.G.,Mascitti, V.; Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.; J. Am. Chem. Soc., 139:3528-3536, 2017; PubMed: 28230359; DOI: 10.1021/jacs.6b12964

実験手法

X-RAY DIFFRACTION (1.83 Å)