5JOG

CRYSTAL STRUCTURE OF CSN5(2-257) IN COMPLEX WITH CNS5i-3

Summary for 5JOG

Entry DOI	10.2210/pdb5jog/pdb
Descriptor	COP9 signalosome complex subunit 5, ZINC ION, 3-(difluoromethyl)-N-{6-[(5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl}-1-(propan-2-yl)-1H-pyrazole-5-carboxamide, ... (4 entities in total)
Functional Keywords	cop9 signalosome, metal protease, inhibitor, hydroxylase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q92905
Total number of polymer chains	1
Total formula weight	29521.95
Authors	Renatus, M.,Wiesmann, C. (deposition date: 2016-05-02, release date: 2016-11-02, Last modification date: 2024-01-10)
Primary citation	Schlierf, A.,Altmann, E.,Quancard, J.,Jefferson, A.B.,Assenberg, R.,Renatus, M.,Jones, M.,Hassiepen, U.,Schaefer, M.,Kiffe, M.,Weiss, A.,Wiesmann, C.,Sedrani, R.,Eder, J.,Martoglio, B. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun, 7:13166-13166, 2016 Cited by PubMed: 27774986 DOI: 10.1038/ncomms13166 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.46 Å)

Structure validation