5JLV

Receptor binding domain of Botulinum neurotoxin A in complex with human glycosylated SV2C

5JLV の概要

• エントリーDOI: 10.2210/pdb5jlv/pdb
• 分子名称: Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: glycosylation, botulinum neurotoxin, receptor binding domain, hydrolase
• 由来する生物種: Clostridium botulinum; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128923.30

構造登録者

Yao, G.,Zhang, S.,Mahrhold, S.,Lam, K.,Stern, D.,Bagramyan, K.,Perry, K.,Kalkum, M.,Rummel, A.,Dong, M.,Jin, R. (登録日: 2016-04-27, 公開日: 2016-06-15, 最終更新日: 2023-09-27)

• 主引用文献: Yao, G.,Zhang, S.,Mahrhold, S.,Lam, K.H.,Stern, D.,Bagramyan, K.,Perry, K.,Kalkum, M.,Rummel, A.,Dong, M.,Jin, R.; N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.; Nat.Struct.Mol.Biol., 23:656-662, 2016; PubMed: 27294781; DOI: 10.1038/nsmb.3245

実験手法

X-RAY DIFFRACTION (2 Å)