5JLG
The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and compound I, a piano-stool organometallic Ru(II) arene compound containing an O,S-chelating ligand
Summary for 5JLG
Entry DOI | 10.2210/pdb5jlg/pdb |
Descriptor | Ribonuclease pancreatic, RUTHENIUM ION, methyl (2Z)-3-hydroxy-3-(3-hydroxyphenyl)prop-2-ene(dithioate), ... (5 entities in total) |
Functional Keywords | ruthenated protein, protein-ru compound adducts, hydrolase, piano-stool organometallic ru(ii) arene compounds |
Biological source | Bos taurus (Cattle) |
Cellular location | Secreted: P61823 |
Total number of polymer chains | 2 |
Total formula weight | 28305.82 |
Authors | Ferraro, G.,Merlino, A. (deposition date: 2016-04-27, release date: 2016-08-03, Last modification date: 2024-01-10) |
Primary citation | Hildebrandt, J.,Gorls, H.,Hafner, N.,Ferraro, G.,Durst, M.,Runnebaum, I.B.,Weigand, W.,Merlino, A. Unusual mode of protein binding by a cytotoxic pi-arene ruthenium(ii) piano-stool compound containing an O,S-chelating ligand. Dalton Trans, 45:12283-12287, 2016 Cited by PubMed: 27427335DOI: 10.1039/c6dt02380k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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