5JKG

The crystal structure of FGFR4 kinase domain in complex with LY2874455

5JKG の概要

• エントリーDOI: 10.2210/pdb5jkg/pdb
• 分子名称: Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol (3 entities in total)
• 機能のキーワード: kinase, small-molecule inhibitor, atp binding pocket, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Cytoplasm : P22455
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35135.39

構造登録者

Wu, D.,Chen, L.,Chen, Y. (登録日: 2016-04-26, 公開日: 2016-10-05, 最終更新日: 2024-03-20)

• 主引用文献: Wu, D.,Guo, M.,Philips, M.A.,Qu, L.,Jiang, L.,Li, J.,Chen, X.,Chen, Z.,Chen, L.,Chen, Y.; Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455; Plos One, 11:e0162491-e0162491, 2016; PubMed: 27618313; DOI: 10.1371/journal.pone.0162491

実験手法

X-RAY DIFFRACTION (2.352 Å)