5JIK

Crystal structure of HER2 binding IgG1-Fc (Fcab H10-03-6)

5JIK の概要

• エントリーDOI: 10.2210/pdb5jik/pdb
• 関連するPDBエントリー: 5JIH 5JII
• 分子名称: Ig gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: immune system, antibody engineering, immunoglobulin g1, fc fragment, glycosylations, ch3 domain, fcab, her2, erbb-2
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted : P01857
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53306.96

構造登録者

Humm, A.,Lobner, E.,Mlynek, G.,Obinger, C.,Djinovic-Carugo, K. (登録日: 2016-04-22, 公開日: 2017-04-12, 最終更新日: 2024-01-10)

• 主引用文献: Lobner, E.,Humm, A.S.,Goritzer, K.,Mlynek, G.,Puchinger, M.G.,Hasenhindl, C.,Ruker, F.,Traxlmayr, M.W.,Djinovic-Carugo, K.,Obinger, C.; Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.; Structure, 25:878-889.e5, 2017; PubMed: 28528777; DOI: 10.1016/j.str.2017.04.014

実験手法

X-RAY DIFFRACTION (1.82 Å)