5JIC

Staphylococcus aureus Type II pantothenate kinase in complex with a pantothenate analog

Summary for 5JIC

Entry DOI	10.2210/pdb5jic/pdb
Descriptor	Type II pantothenate kinase, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	pantothenamide, inhibitor, antimicrobial, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Staphylococcus aureus (strain MW2)
Cellular location	Cytoplasm : Q8NVG0
Total number of polymer chains	1
Total formula weight	30805.71
Authors	Hughes, S.J.,Antoshchenko, T.,Mottaghi, K.,Barnard, L.,Strauss, E.,Park, H. (deposition date: 2016-04-22, release date: 2016-08-10, Last modification date: 2023-09-27)
Primary citation	Hughes, S.J.,Barnard, L.,Mottaghi, K.,Tempel, W.,Antoshchenko, T.,Hong, B.S.,Allali-Hassani, A.,Smil, D.,Vedadi, M.,Strauss, E.,Park, H.W. Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product. Acs Infect Dis., 2:627-641, 2016 Cited by PubMed: 27759386 DOI: 10.1021/acsinfecdis.6b00090 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation