5JI1

Crystal Structure of GDF8

Summary for 5JI1

• Entry DOI: 10.2210/pdb5ji1/pdb
• Related: 5JHW
• Descriptor: Growth/differentiation factor 8, (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total)
• Functional Keywords: gdf8, myostatin, tgfbeta, ligand, cytokine
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 2
• Total formula weight: 25671.64

Authors

Walker, R.G.,Thompson, T.B. (deposition date: 2016-04-21, release date: 2017-03-22, Last modification date: 2024-11-06)

Primary citation

Walker, R.G.,Czepnik, M.,Goebel, E.J.,McCoy, J.C.,Vujic, A.,Cho, M.,Oh, J.,Aykul, S.,Walton, K.L.,Schang, G.,Bernard, D.J.,Hinck, A.P.,Harrison, C.A.,Martinez-Hackert, E.,Wagers, A.J.,Lee, R.T.,Thompson, T.B.
Structural basis for potency differences between GDF8 and GDF11.
BMC Biol., 15:19-19, 2017

PubMed Abstract: Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members of the transforming growth factor β (TGFβ) family. While GDF8 has been recognized as a negative regulator of muscle growth and differentiation, there are conflicting studies on the function of GDF11 and whether GDF11 has beneficial effects on age-related dysfunction. To address whether GDF8 and GDF11 are functionally identical, we compared their signaling and structural properties.

PubMed: 28257634
DOI: 10.1186/s12915-017-0350-1

Experimental method

X-RAY DIFFRACTION (2.25 Å)