5JHP

Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L179A and I195A mutant in complex with rice D53 repressor EAR peptide motif

Summary for 5JHP

Entry DOI	10.2210/pdb5jhp/pdb
Related	5J9K 5JA5 5JGC
Descriptor	Protein TPR1, The rice D53 EAR peptide (794-808) (2 entities in total)
Functional Keywords	transcription repression, transcriptional corepressor topless, alpha-helical structure, tetramer, transcriptional repressor d53, transcription
Biological source	Oryza sativa (Rice) More
Total number of polymer chains	5
Total formula weight	101142.76
Authors	Ke, J.,Ma, H.,Gu, X.,Brunzelle, J.S.,Xu, H.E.,Melcher, K. (deposition date: 2016-04-21, release date: 2017-07-05, Last modification date: 2023-09-27)
Primary citation	Ma, H.,Duan, J.,Ke, J.,He, Y.,Gu, X.,Xu, T.H.,Yu, H.,Wang, Y.,Brunzelle, J.S.,Jiang, Y.,Rothbart, S.B.,Xu, H.E.,Li, J.,Melcher, K. A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Sci Adv, 3:e1601217-e1601217, 2017 Cited by PubMed: 28630893 DOI: 10.1126/sciadv.1601217 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.15 Å)

Structure validation