Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L111A, L130A, L179A and I195A mutant

Summary for 5JGC

Related5J9K 5JA5 5JHP
DescriptorProtein TPR1, ZINC ION (3 entities in total)
Functional Keywordstranscription repression, transcriptional corepressor topless, alpha-helical structure, tetramer, transcriptional repressor d53, transcription
Biological sourceOryza sativa (Rice)
Total number of polymer chains1
Total molecular weight24800.7
Ke, J.,Ma, H.,Gu, X.,Brunzelle, J.S.,Xu, H.E.,Melcher, K. (deposition date: 2016-04-20, release date: 2017-07-05, Last modification date: 2019-12-25)
Primary citation
Ma, H.,Duan, J.,Ke, J.,He, Y.,Gu, X.,Xu, T.H.,Yu, H.,Wang, Y.,Brunzelle, J.S.,Jiang, Y.,Rothbart, S.B.,Xu, H.E.,Li, J.,Melcher, K.
A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3:e1601217-e1601217, 2017
PubMed: 28630893 (PDB entries with the same primary citation)
DOI: 10.1126/sciadv.1601217
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.246203.9%10.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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