5JG8

Crystal structure of human acid sphingomyelinase

Summary for 5JG8

• Entry DOI: 10.2210/pdb5jg8/pdb
• Descriptor: Sphingomyelin phosphodiesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: lysosomal hydrolase, neimann-pick disease, sphingolipid, saposin, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 135427.76

Authors

Xiong, Z.J.,Prive, G.G. (deposition date: 2016-04-19, release date: 2016-07-06, Last modification date: 2023-09-27)

• Primary citation: Xiong, Z.J.,Huang, J.,Poda, G.,Pomes, R.,Prive, G.G.; Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis.; J.Mol.Biol., 428:3026-3042, 2016; PubMed: 27349982; DOI: 10.1016/j.jmb.2016.06.012

Experimental method

X-RAY DIFFRACTION (2.8 Å)