5JG8

Crystal structure of human acid sphingomyelinase

5JG8 の概要

• エントリーDOI: 10.2210/pdb5jg8/pdb
• 分子名称: Sphingomyelin phosphodiesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: lysosomal hydrolase, neimann-pick disease, sphingolipid, saposin, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 135427.76

構造登録者

Xiong, Z.J.,Prive, G.G. (登録日: 2016-04-19, 公開日: 2016-07-06, 最終更新日: 2023-09-27)

• 主引用文献: Xiong, Z.J.,Huang, J.,Poda, G.,Pomes, R.,Prive, G.G.; Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis.; J.Mol.Biol., 428:3026-3042, 2016; PubMed: 27349982; DOI: 10.1016/j.jmb.2016.06.012

実験手法

X-RAY DIFFRACTION (2.8 Å)