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5JFR

Potent, Reversible MetAP2 Inhibitors via Fragment Based Drug Discovery

Summary for 5JFR
Entry DOI10.2210/pdb5jfr/pdb
Related5JHU 5JI6
DescriptorMethionine aminopeptidase 2, MANGANESE (II) ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywordshydrolase, peptidase, metal ion binding, proteolysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : P50579
Total number of polymer chains1
Total formula weight41912.35
Authors
Dougan, D.R.,Lawson, J.D. (deposition date: 2016-04-19, release date: 2016-05-25, Last modification date: 2016-06-15)
Primary citationMcBride, C.,Cheruvallath, Z.,Komandla, M.,Tang, M.,Farrell, P.,Lawson, J.D.,Vanderpool, D.,Wu, Y.,Dougan, D.R.,Plonowski, A.,Holub, C.,Larson, C.
Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 2.
Bioorg.Med.Chem.Lett., 26:2779-2783, 2016
Cited by
PubMed: 27136719
DOI: 10.1016/j.bmcl.2016.04.072
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

217705

건을2024-03-27부터공개중

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