5JFR
Potent, Reversible MetAP2 Inhibitors via Fragment Based Drug Discovery
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Methionine aminopeptidase 2 | polymer | 369 | 41356.0 | 1 | UniProt (P50579) Pfam (PF00557) | Homo sapiens (Human) | MetAP 2,Initiation factor 2-associated 67 kDa glycoprotein,p67eIF2,Peptidase M |
| 2 | B, C (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 3 | D (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 4 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | F (A) | 7-fluoro-4-(5-methyl-3H-imidazo[4,5-b]pyridin-6-yl)-2,4-dihydropyrazolo[4,3-b]indole | non-polymer | 306.3 | 1 | Chemie (6KP) | |||
| 6 | G (A) | water | water | 18.0 | 340 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41356.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 556.4 | |
| All* | Total formula weight | 41912.4 |
