5JEB

Crystal structure of EGFR tyrosine kinase domain with novel inhibitor of active state of HER2

5JEB の概要

• エントリーDOI: 10.2210/pdb5jeb/pdb
• 分子名称: Epidermal growth factor receptor, SULFATE ION, 3-(furan-2-yl)-N-[5-(furan-2-yl)-2-methoxyphenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
• 機能のキーワード: inhibitor, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39122.07

構造登録者

Park, J.H.,Lemmon, M.A. (登録日: 2016-04-18, 公開日: 2016-09-07, 最終更新日: 2023-09-27)

• 主引用文献: Novotny, C.J.,Pollari, S.,Park, J.H.,Lemmon, M.A.,Shen, W.,Shokat, K.M.; Overcoming resistance to HER2 inhibitors through state-specific kinase binding.; Nat.Chem.Biol., 12:923-930, 2016; PubMed: 27595329; DOI: 10.1038/nchembio.2171

実験手法

X-RAY DIFFRACTION (3.298 Å)