5JDI

Trypanosoma brucei PTR1 in complex with cofactor and inhibitor NMT-H024 (compound 2)

Summary for 5JDI

Entry DOI	10.2210/pdb5jdi/pdb
Descriptor	Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ACETATE ION, ... (6 entities in total)
Functional Keywords	trypanosoma brucei, pteridine reductase, oxydoreductase, inhibitor, oxidoreductase
Biological source	Trypanosoma brucei brucei More
Total number of polymer chains	4
Total formula weight	126656.62
Authors	Landi, G.,Pozzi, C.,Di Pisa, F.,Dello lacono, L.,Mangani, S. (deposition date: 2016-04-16, release date: 2016-08-17, Last modification date: 2024-01-10)
Primary citation	Borsari, C.,Luciani, R.,Pozzi, C.,Poehner, I.,Henrich, S.,Trande, M.,Cordeiro-da-Silva, A.,Santarem, N.,Baptista, C.,Tait, A.,Di Pisa, F.,Dello Iacono, L.,Landi, G.,Gul, S.,Wolf, M.,Kuzikov, M.,Ellinger, B.,Reinshagen, J.,Witt, G.,Gribbon, P.,Kohler, M.,Keminer, O.,Behrens, B.,Costantino, L.,Tejera Nevado, P.,Bifeld, E.,Eick, J.,Clos, J.,Torrado, J.,Jimenez-Anton, M.D.,Corral, M.J.,Alunda, J.M.,Pellati, F.,Wade, R.C.,Ferrari, S.,Mangani, S.,Costi, M.P. Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs. J.Med.Chem., 59:7598-7616, 2016 Cited by PubMed: 27411733 DOI: 10.1021/acs.jmedchem.6b00698 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.38 Å)

Structure validation