5JC7
Crystal structure of chicken MDA5 with 5'p 24-mer dsRNA and ADP-Mg2+ at 2.75 A resolution.
Summary for 5JC7
Entry DOI | 10.2210/pdb5jc7/pdb |
Descriptor | Melanoma differentiation associated protein-5, RNA (5'-R(P*GP*GP*AP*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*GP*UP*CP*CP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*AP*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*GP*UP*CP*CP*C)-3'), ... (6 entities in total) |
Functional Keywords | innate immune pattern recognition receptor, rig-i like helicase, dsrna dependent atpase, zinc-containing ctd domain, immune system |
Biological source | Gallus gallus (Chicken) More |
Total number of polymer chains | 4 |
Total formula weight | 180072.29 |
Authors | Cusack, S.,Uchikawa, E. (deposition date: 2016-04-14, release date: 2016-06-01, Last modification date: 2024-01-10) |
Primary citation | Uchikawa, E.,Lethier, M.,Malet, H.,Brunel, J.,Gerlier, D.,Cusack, S. Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62:586-602, 2016 Cited by PubMed: 27203181DOI: 10.1016/j.molcel.2016.04.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
Download full validation report