5JBC

Crystal structure of factor IXa variant V16I K98T Y177T I213V in complex with PPACK

Summary for 5JBC

• Entry DOI: 10.2210/pdb5jbc/pdb
• Related PRD ID: PRD_000020
• Descriptor: Coagulation factor IX, CALCIUM ION, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (5 entities in total)
• Functional Keywords: crystal structure of factor ixa variant k98t in complex with egr-chloromethylketone, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted : P00740 P00740
• Total number of polymer chains: 2
• Total formula weight: 32990.03

Authors

Kristensen, L.H.,Brandstetter, H. (deposition date: 2016-04-13, release date: 2016-06-01, Last modification date: 2024-01-10)

• Primary citation: Kristensen, L.H.,Olsen, O.H.,Blouse, G.E.,Brandstetter, H.; Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.; Biochem.J., 473:2395-2411, 2016; PubMed: 27208168; DOI: 10.1042/BCJ20160336

Experimental method

X-RAY DIFFRACTION (1.9 Å)