5JAX

PKG I's Carboyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-Br-cGMP

5JAX の概要

• エントリーDOI: 10.2210/pdb5jax/pdb
• 分子名称: cGMP-dependent protein kinase 1, 2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: binding sites, cyclic amp, cyclic gmp, cyclic gmp-dependent protein kinase type ii, mutagenesis, site-directed, protein binding, analogs, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q13976
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15513.99

構造登録者

Campbell, J.C.,Sankaran, B.,Kim, C.W. (登録日: 2016-04-12, 公開日: 2017-04-19, 最終更新日: 2023-09-27)

• 主引用文献: Campbell, J.C.,Henning, P.,Franz, E.,Sankaran, B.,Herberg, F.W.,Kim, C.; Structural Basis of Analog Specificity in PKG I and II.; ACS Chem. Biol., 12:2388-2398, 2017; PubMed: 28793191; DOI: 10.1021/acschembio.7b00369

実験手法

X-RAY DIFFRACTION (1.486 Å)