5JAT

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) Discovered Through X-Ray Fragment Screening

Summary for 5JAT

Entry DOI	10.2210/pdb5jat/pdb
Descriptor	Platelet-activating factor acetylhydrolase, CHLORIDE ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	phospholipase, lipid metabolism, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	44655.18
Authors	Day, P.J. (deposition date: 2016-04-12, release date: 2016-05-25, Last modification date: 2019-10-16)
Primary citation	Woolford, A.J.,Pero, J.E.,Aravapalli, S.,Berdini, V.,Coyle, J.E.,Day, P.J.,Dodson, A.M.,Grondin, P.,Holding, F.P.,Lee, L.Y.,Li, P.,Manas, E.S.,Marino, J.,Martin, A.C.,McCleland, B.W.,McMenamin, R.L.,Murray, C.W.,Neipp, C.E.,Page, L.W.,Patel, V.K.,Potvain, F.,Rich, S.,Rivero, R.A.,Smith, K.,Somers, D.O.,Trottet, L.,Velagaleti, R.,Williams, G.,Xie, R. Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59:5356-5367, 2016 Cited by PubMed: 27167608 DOI: 10.1021/acs.jmedchem.6b00212 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation