5J9X
HSP90 in complex with N-Butyl-5-[4-(2-fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-2,4-dihydroxy-N-methyl-benzamide
Summary for 5J9X
Entry DOI | 10.2210/pdb5j9x/pdb |
Descriptor | Heat shock protein HSP 90-alpha, N-butyl-5-[4-(2-fluorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]-2,4-dihydroxy-N-methylbenzamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | inhibitor, chaperone |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P07900 |
Total number of polymer chains | 1 |
Total formula weight | 25806.00 |
Authors | Amaral, M.,Matias, P. (deposition date: 2016-04-11, release date: 2017-12-06, Last modification date: 2024-01-10) |
Primary citation | Amaral, M.,Kokh, D.B.,Bomke, J.,Wegener, A.,Buchstaller, H.P.,Eggenweiler, H.M.,Matias, P.,Sirrenberg, C.,Wade, R.C.,Frech, M. Protein conformational flexibility modulates kinetics and thermodynamics of drug binding. Nat Commun, 8:2276-2276, 2017 Cited by PubMed: 29273709DOI: 10.1038/s41467-017-02258-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report