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5J9X

HSP90 in complex with N-Butyl-5-[4-(2-fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-2,4-dihydroxy-N-methyl-benzamide

Summary for 5J9X
Entry DOI10.2210/pdb5j9x/pdb
DescriptorHeat shock protein HSP 90-alpha, N-butyl-5-[4-(2-fluorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]-2,4-dihydroxy-N-methylbenzamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywordsinhibitor, chaperone
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : P07900
Total number of polymer chains1
Total formula weight25806.00
Authors
Amaral, M.,Matias, P. (deposition date: 2016-04-11, release date: 2017-12-06, Last modification date: 2024-01-10)
Primary citationAmaral, M.,Kokh, D.B.,Bomke, J.,Wegener, A.,Buchstaller, H.P.,Eggenweiler, H.M.,Matias, P.,Sirrenberg, C.,Wade, R.C.,Frech, M.
Protein conformational flexibility modulates kinetics and thermodynamics of drug binding.
Nat Commun, 8:2276-2276, 2017
Cited by
PubMed: 29273709
DOI: 10.1038/s41467-017-02258-w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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