5J9M
tRNA guanine Transglycosylase (TGT) in co-crystallized complex with 2-(methylamino)-1H-benzo[d]imidazole-5-carboxamide
Summary for 5J9M
Entry DOI | 10.2210/pdb5j9m/pdb |
Related | 1P0D 3S1G 4KWO 4PUK 5I07 |
Descriptor | Queuine tRNA-ribosyltransferase, 2-(methylamino)-1H-benzimidazole-5-carboxamide, GLYCEROL, ... (7 entities in total) |
Functional Keywords | benzimidazole-derivatives, shigellosis, transferase, transferase inhibitor |
Biological source | Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) |
Total number of polymer chains | 1 |
Total formula weight | 43463.02 |
Authors | Ehrmann, F.R.,Heine, A.,Klebe, G. (deposition date: 2016-04-10, release date: 2017-05-24, Last modification date: 2024-01-10) |
Primary citation | Ehrmann, F.R.,Hohn, C.,Heine, A.,Diederich, F.,Klebe, G. Benzimidazole-based Inhibitors as a Novel Scaffold to Inhibit Z.mobilis TGT and Study Protein Flexibility and the Contributions of Active Site Residues to Binding Affinity of lin-Benzopurines. To be Published, |
Experimental method | X-RAY DIFFRACTION (1.33 Å) |
Structure validation
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