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5J5Z

Crystal structure of the D444V disease-causing mutant of the human dihydrolipoamide dehydrogenase

Summary for 5J5Z
Entry DOI10.2210/pdb5j5z/pdb
DescriptorDihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordsdihydrolipoamide dehydrogenase, e3 subunit, disease-causing mutant, e3 deficiency, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight107279.75
Authors
Szabo, E.,Mizsei, R.,Zambo, Z.,Torocsik, B.,Weiss, M.S.,Adam-Vizi, V.,Ambrus, A. (deposition date: 2016-04-04, release date: 2017-11-15, Last modification date: 2024-01-10)
Primary citationSzabo, E.,Mizsei, R.,Wilk, P.,Zambo, Z.,Torocsik, B.,Weiss, M.S.,Adam-Vizi, V.,Ambrus, A.
Crystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenase.
Free Radic. Biol. Med., 124:214-220, 2018
Cited by
PubMed: 29908278
DOI: 10.1016/j.freeradbiomed.2018.06.008
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.84 Å)
Structure validation

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