5J5Y

Translation initiation factor 4E in complex with m2(7,2'O)GppCCl2ppG mRNA 5' cap analog

5J5Y の概要

• エントリーDOI: 10.2210/pdb5j5y/pdb
• 分子名称: Eukaryotic translation initiation factor 4E, 2-amino-9-{5-O-[(R)-{[(S)-{dichloro[(R)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2-O-methyl-beta-D-ribofuranosyl}-7-methyl-9H-purin-7-ium-6-olate, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: protein-ligand complex, translation initiation factor, eif4e, m2(7, 2'o)gppccl2ppg, dichloromethylenebisphosphonate, mrna 5' cap analog, translation
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 90068.81

構造登録者

Warminski, M.,Nowak, E.,Rydzik, A.M.,Kowalska, J.,Jemielity, J.,Nowotny, M. (登録日: 2016-04-04, 公開日: 2017-05-10, 最終更新日: 2024-01-10)

• 主引用文献: Rydzik, A.M.,Warminski, M.,Sikorski, P.J.,Baranowski, M.R.,Walczak, S.,Kowalska, J.,Zuberek, J.,Lukaszewicz, M.,Nowak, E.,W Claridge, T.D.,Darzynkiewicz, E.,Nowotny, M.,Jemielity, J.; mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation.; Nucleic Acids Res., 45:8661-8675, 2017; PubMed: 28666355; DOI: 10.1093/nar/gkx569

実験手法

X-RAY DIFFRACTION (1.75 Å)