5J5S

Src kinase in complex with a sulfonamide inhibitor

5J5S の概要

• エントリーDOI: 10.2210/pdb5j5s/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, N-{4-[8-amino-3-(propan-2-yl)imidazo[1,5-a]pyrazin-1-yl]naphthalen-1-yl}-N'-[3-(trifluoromethyl)phenyl]urea (3 entities in total)
• 機能のキーワード: protein kinase, inactive kinase, sulfonamide inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Gallus gallus (Chicken)
• 細胞内の位置: Cell membrane : P00523
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66462.30

構造登録者

Lebedev, I.,Feldman, H.C.,Georghiou, G.,Maly, D.J.,Seeliger, M. (登録日: 2016-04-03, 公開日: 2016-06-01, 最終更新日: 2023-09-27)

• 主引用文献: Feldman, H.C.,Tong, M.,Wang, L.,Meza-Acevedo, R.,Gobillot, T.A.,Gliedt, M.J.,Hari, S.B.,Mitra, A.K.,Backes, B.J.,Papa, F.R.,Seeliger, M.A.,Maly, D.J.; Structural and Functional Analysis of the Allosteric Modulation of IRE1a with ATP-Competitive Kinase Inhibitors; To Be Published,

実験手法

X-RAY DIFFRACTION (2.153 Å)