5J4C
Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution
This is a non-PDB format compatible entry.
Summary for 5J4C
Entry DOI | 10.2210/pdb5j4c/pdb |
Related | 5J4B |
Descriptor | 23S ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total) |
Functional Keywords | ribosome, cisplatin, anticancer drug, cytotoxicity, inhibition of translation, translocation, mrna channel, gtpase activating center |
Biological source | Escherichia coli More |
Total number of polymer chains | 112 |
Total formula weight | 4579483.08 |
Authors | Melnikov, S.V.,Soll, D.,Steitz, T.A.,Polikanov, Y.S. (deposition date: 2016-03-31, release date: 2016-04-27, Last modification date: 2023-11-15) |
Primary citation | Melnikov, S.V.,Soll, D.,Steitz, T.A.,Polikanov, Y.S. Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome. Nucleic Acids Res., 44:4978-4987, 2016 Cited by PubMed: 27079977DOI: 10.1093/nar/gkw246 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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