5J2T

Tubulin-vinblastine complex

Summary for 5J2T

• Entry DOI: 10.2210/pdb5j2t/pdb
• Related: 5IYZ
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Tubulin beta-2B chain, ... (11 entities in total)
• Functional Keywords: cell cycle, cytoskeleton, tubulin fold, microtubule
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 264683.29

Authors

Waight, A.B.,Bargsten, K.,Doronina, S.,Steinmetz, M.O.,Sussman, D.,Prota, A.E. (deposition date: 2016-03-30, release date: 2016-08-17, Last modification date: 2024-01-10)

• Primary citation: Waight, A.B.,Bargsten, K.,Doronina, S.,Steinmetz, M.O.,Sussman, D.,Prota, A.E.; Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.; Plos One, 11:e0160890-e0160890, 2016; PubMed: 27518442; DOI: 10.1371/journal.pone.0160890

Experimental method

X-RAY DIFFRACTION (2.2 Å)