5IXS

Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 9: (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one

5IXS の概要

• エントリーDOI: 10.2210/pdb5ixs/pdb
• 関連するPDBエントリー: 5IXY
• 分子名称: L-lactate dehydrogenase A chain, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... (7 entities in total)
• 機能のキーワード: oxidoreductase tetramer, oxireductase-oxireductase inhibitor complex, oxireductase/oxireductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P00338
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 151900.63

構造登録者

Ultsch, M.,Eigenbrot, C. (登録日: 2016-03-23, 公開日: 2016-09-14, 最終更新日: 2023-09-27)

• 主引用文献: Purkey, H.E.,Robarge, K.,Chen, J.,Chen, Z.,Corson, L.B.,Ding, C.Z.,DiPasquale, A.G.,Dragovich, P.S.,Eigenbrot, C.,Evangelista, M.,Fauber, B.P.,Gao, Z.,Ge, H.,Hitz, A.,Ho, Q.,Labadie, S.S.,Lai, K.W.,Liu, W.,Liu, Y.,Li, C.,Ma, S.,Malek, S.,O'Brien, T.,Pang, J.,Peterson, D.,Salphati, L.,Sideris, S.,Ultsch, M.,Wei, B.,Yen, I.,Yue, Q.,Zhang, H.,Zhou, A.; Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.; Acs Med.Chem.Lett., 7:896-901, 2016; PubMed: 27774125; DOI: 10.1021/acsmedchemlett.6b00190

実験手法

X-RAY DIFFRACTION (2.05 Å)