5IXI
Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera
Summary for 5IXI
Entry DOI | 10.2210/pdb5ixi/pdb |
Related | 5IXD |
Descriptor | Tyrosine-protein kinase JAK1, Chimera protein of Interferon lambda receptor 1 and Interleukin-10 receptor subunit alpha (3 entities in total) |
Functional Keywords | jak kinase, jak1, ifnlr1, il10, il10ra, interferon, cytokine |
Biological source | Homo sapiens (Human) More |
Cellular location | Endomembrane system; Peripheral membrane protein: P23458 Membrane; Single-pass type I membrane protein: Q13651 |
Total number of polymer chains | 2 |
Total formula weight | 69498.40 |
Authors | Ferrao, R.,Wallweber, H.J.A.,Lupardus, P.J. (deposition date: 2016-03-23, release date: 2016-05-18, Last modification date: 2023-09-27) |
Primary citation | Ferrao, R.,Wallweber, H.J.,Ho, H.,Tam, C.,Franke, Y.,Quinn, J.,Lupardus, P.J. The Structural Basis for Class II Cytokine Receptor Recognition by JAK1. Structure, 24:897-905, 2016 Cited by PubMed: 27133025DOI: 10.1016/j.str.2016.03.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.57 Å) |
Structure validation
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