5IXI

Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera

Summary for 5IXI

• Entry DOI: 10.2210/pdb5ixi/pdb
• Related: 5IXD
• Descriptor: Tyrosine-protein kinase JAK1, Chimera protein of Interferon lambda receptor 1 and Interleukin-10 receptor subunit alpha (3 entities in total)
• Functional Keywords: jak kinase, jak1, ifnlr1, il10, il10ra, interferon, cytokine
• Biological source: Homo sapiens (Human); More
• Cellular location: Endomembrane system; Peripheral membrane protein: P23458; Membrane; Single-pass type I membrane protein: Q13651
• Total number of polymer chains: 2
• Total formula weight: 69498.40

Authors

Ferrao, R.,Wallweber, H.J.A.,Lupardus, P.J. (deposition date: 2016-03-23, release date: 2016-05-18, Last modification date: 2023-09-27)

• Primary citation: Ferrao, R.,Wallweber, H.J.,Ho, H.,Tam, C.,Franke, Y.,Quinn, J.,Lupardus, P.J.; The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.; Structure, 24:897-905, 2016; PubMed: 27133025; DOI: 10.1016/j.str.2016.03.023

Experimental method

X-RAY DIFFRACTION (2.57 Å)