5IX7

Crystal structure of metallo-DNA nanowire with infinite one-dimensional silver array

Summary for 5IX7

• Entry DOI: 10.2210/pdb5ix7/pdb
• Descriptor: DNA (5'-D(*GP*GP*AP*CP*TP*(CBR)P*GP*AP*CP*TP*CP*C)-3'), SILVER ION, POTASSIUM ION, ... (4 entities in total)
• Functional Keywords: dna, nanowire, x-ray analysis, metallo-base pairs, silver
• Biological source: synthetic construct
• Total number of polymer chains: 1
• Total formula weight: 4427.67

Authors

Kondo, J.,Tada, Y.,Dairaku, T.,Hattori, Y.,Saneyoshi, H.,Ono, A.,Tanaka, Y. (deposition date: 2016-03-23, release date: 2017-07-05, Last modification date: 2024-03-20)

Primary citation

Kondo, J.,Tada, Y.,Dairaku, T.,Hattori, Y.,Saneyoshi, H.,Ono, A.,Tanaka, Y.
A metallo-DNA nanowire with uninterrupted one-dimensional silver array
Nat Chem, 9:956-960, 2017

PubMed Abstract: The double-helix structure of DNA, in which complementary strands reversibly hybridize to each other, not only explains how genetic information is stored and replicated, but also has proved very attractive for the development of nanomaterials. The discovery of metal-mediated base pairs has prompted the generation of short metal-DNA hybrid duplexes by a bottom-up approach. Here we describe a metallo-DNA nanowire-whose structure was solved by high-resolution X-ray crystallography-that consists of dodecamer duplexes held together by four different metal-mediated base pairs (the previously observed C-Ag-C, as well as G-Ag-G, G-Ag-C and T-Ag-T) and linked to each other through G overhangs involved in interduplex G-Ag-G. The resulting hybrid nanowires are 2 nm wide with a length of the order of micrometres to millimetres, and hold the silver ions in uninterrupted one-dimensional arrays along the DNA helical axis. The hybrid nanowires are further assembled into three-dimensional lattices by interactions between adenine residues, fully bulged out of the double helix.

PubMed: 28937663
DOI: 10.1038/nchem.2808

Experimental method

X-RAY DIFFRACTION (1.398 Å)