5IWM
2.5A structure of GSK945237 with S.aureus DNA gyrase and DNA.
Summary for 5IWM
Entry DOI | 10.2210/pdb5iwm/pdb |
Descriptor | DNA gyrase subunit B,DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*TP*CP*AP*CP*CP*GP*CP*AP*CP*A)-3'), ... (8 entities in total) |
Functional Keywords | type iia topoisomerase, antibacterial, inhibitor, isomerase, fusion protein |
Biological source | Staphylococcus aureus More |
Cellular location | Cytoplasm : P66937 Q99XG5 |
Total number of polymer chains | 6 |
Total formula weight | 169177.40 |
Authors | Bax, B.D.,Miles, T.J. (deposition date: 2016-03-22, release date: 2016-05-25, Last modification date: 2024-01-10) |
Primary citation | Miles, T.J.,Hennessy, A.J.,Bax, B.,Brooks, G.,Brown, B.S.,Brown, P.,Cailleau, N.,Chen, D.,Dabbs, S.,Davies, D.T.,Esken, J.M.,Giordano, I.,Hoover, J.L.,Jones, G.E.,Kusalakumari Sukmar, S.K.,Markwell, R.E.,Minthorn, E.A.,Rittenhouse, S.,Gwynn, M.N.,Pearson, N.D. Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases. Bioorg.Med.Chem.Lett., 26:2464-2469, 2016 Cited by PubMed: 27055939DOI: 10.1016/j.bmcl.2016.03.106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report