5IWI

1.98A structure of GSK945237 with S.aureus DNA gyrase and singly nicked DNA

Summary for 5IWI

• Entry DOI: 10.2210/pdb5iwi/pdb
• Descriptor: DNA gyrase subunit B,DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*AP*CP*CP*GP*CP*AP*CP*A)-3'), ... (10 entities in total)
• Functional Keywords: type iia topoisomerase, antibacterial, inhibitor, isomerase, fusion protein
• Biological source: Staphylococcus aureus; More
• Cellular location: Cytoplasm : P66937 Q99XG5
• Total number of polymer chains: 7
• Total formula weight: 170051.68

Authors

Bax, B.D.,Miles, T.J. (deposition date: 2016-03-22, release date: 2016-05-25, Last modification date: 2024-01-10)

• Primary citation: Miles, T.J.,Hennessy, A.J.,Bax, B.,Brooks, G.,Brown, B.S.,Brown, P.,Cailleau, N.,Chen, D.,Dabbs, S.,Davies, D.T.,Esken, J.M.,Giordano, I.,Hoover, J.L.,Jones, G.E.,Kusalakumari Sukmar, S.K.,Markwell, R.E.,Minthorn, E.A.,Rittenhouse, S.,Gwynn, M.N.,Pearson, N.D.; Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.; Bioorg.Med.Chem.Lett., 26:2464-2469, 2016; PubMed: 27055939; DOI: 10.1016/j.bmcl.2016.03.106

Experimental method

X-RAY DIFFRACTION (1.98 Å)