5IV4

Crystal structure of the human soluble adenylyl cyclase in complex with the allosteric inhibitor LRE1

5IV4 の概要

• エントリーDOI: 10.2210/pdb5iv4/pdb
• 分子名称: Adenylate cyclase type 10, 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine, ACETATE ION, ... (9 entities in total)
• 機能のキーワード: human soluble adenylyl cyclase complex lre1 inhibitor, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side : Q96PN6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55525.07

構造登録者

Kleinboelting, S.,Steegborn, C. (登録日: 2016-03-18, 公開日: 2016-08-17, 最終更新日: 2022-11-30)

• 主引用文献: Ramos-Espiritu, L.,Kleinboelting, S.,Navarrete, F.A.,Alvau, A.,Visconti, P.E.,Valsecchi, F.,Starkov, A.,Manfredi, G.,Buck, H.,Adura, C.,Zippin, J.H.,van den Heuvel, J.,Glickman, J.F.,Steegborn, C.,Levin, L.R.,Buck, J.; Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.; Nat.Chem.Biol., 12:838-844, 2016; PubMed: 27547922; DOI: 10.1038/nchembio.2151

実験手法

X-RAY DIFFRACTION (1.79 Å)